منابع مشابه
Glycine receptors and brain development
Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in different processes including synaptic neurotr...
متن کاملCharacteristics of glycine receptors expressed by embryonic rat brain mRNAs.
A study was made of glycine (Gly) and gamma-aminobutyric acid (GABA) receptors expressed in Xenopus oocytes injected with rat mRNAs isolated from the encephalon, midbrain, and brainstem of 18-day-old rat embryos. In oocytes injected with encephalon, midbrain, or brainstem mRNAs, the Gly-current amplitudes (membrane current elicited by Gly; 1 mM Gly) were respectively 115 +/- 35, 346 +/- 28, and...
متن کاملGlycine receptors regulate interneuron differentiation during spinal network development.
Glycinergic and GABAergic excitatory chloride-mediated signaling is often the first form of activity to emerge in the nascent nervous system and has been proposed to be essential for several aspects of nervous system development. However, few studies have examined the effects of disrupting glycinergic transmission. Here we perturbed glycinergic transmission in vivo from the onset of development...
متن کاملChapter 1 NMDA Receptors and Brain Development
More than 20 years have passed since the discovery that NMDAR-mediated synaptic activity is important for the functional development of sensory brain circuits [1] by specifically regulating the refinement of sensory topographic maps [2]. Since then we have learned in great detail how this receptor shapes the development of neurons and neuronal circuits. The diversity of NMDAR subunits and their...
متن کاملGlycine and glycine receptor immunoreactivity in brain and spinal cord.
To study the distribution of glycine immunoreactive neurons in the spinal cord and brain, antisera were raised against glycine conjugated to protein carriers. High-titer rabbit glycine antiserum was purified by affinity chromatography. Testing against other amino acids and peptides with immuno dot blots and ELISA assays showed little apparent cross-reaction with glutamate, aspartate, glutamine,...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2013
ISSN: 1662-5102
DOI: 10.3389/fncel.2013.00184